Відео

thank you

How painful is it if you deny treatment?

I hope you guys get Dr. Weber to repeat his ASCO 2024 talk on Moderna & Merck's Individualized Neoantigen Therapy. It is annoying that ASCO has kept these exciting developments behind a paywall.

On Friday, 6/21/24, I received a diagnosis of uveal melanoma from Retina Consultants of Texas. I am getting a second opinion from MD Anderson (both facilities are in Houston, TX). Luckily for me, my optometrist saw the "freckle" during a routine exam and referred me to their ophthalmologist, who referred me to Dr. Amy Schefler (Ocular Oncologist) at the Retina Consultants of Texas. This is definitely an uneasy time for me and my family. This video was helpful in clarifying the cancer, and treatments available. Are there other resources you'd suggest? Thank you.

All of interest.

Prof. Weber has fallen into misconception #1 of what the p-value is in Steve Goodman's paper "A dirty dozen: twelve p-value misconceptions" PMID: 18582619. From the paper "The definition of the P value is as follows-in words: The probability of the observed result, plus more extreme results, if the null hypothesis were true...The null hypothesis will be defined as the hypothesis that there is no effect of the intervention.... Misconception #1: If P .05, the null hypothesis has only a 5% chance of being true. This is, without a doubt, the most pervasive and pernicious of the many misconceptions about the P value. It perpetuates the false idea that the data alone can tell us how likely we are to be right or wrong in our conclusions. The simplest way to see that this is false is to note that the P value is calculated under the assumption that the null hypothesis is true. It therefore cannot simultaneously be a probability that the null hypothesis is false. Let us suppose we flip a penny four times and observe four heads, two-sided P .125. This does not mean that the probability of the coin being fair is only 12.5%. The only way we can calculate that probability is by Bayes’ theorem, to be discussed later and in other chapters in this issue of Seminars in Hematology" The paper goes on to say "The most important foundational issue to appreciate is that there is no number generated by standard methods that tells us the probability that a given conclusion is right or wrong."

Many thanks to St. John’s Providence and Dr. Fluke for informing the public regarding treatments for melanoma and why the incision may appear to be on the long side to us lay viewers! This is very informative!

Thank you so much for enhancing my knowledge. Mucosal vag. melanoma at stage 1 - but offered treatment for 2-3 stage conservative opp....which i refused firmly.

Eat A LOT of mini sweep peppers, especially red. FULL of vitamin C. Eat them like apples. No food in a box. Broccoli and chicken. Green Bell peppers. Ginger, cucumber, lemon, lime, parsley. Oregano.

Thank you for this information which I haven’t found elsewhere.

I had my surgery a week ago wide excision and lymph nodes removed. They said I was an unusual case they do not normally remove all the nodes without proof but both the ct scan and pet scan showed enlarged nodes and they did try biopsy the nodes but this was negative but they said in there experience based on scans more likely to be positive so better to remove them so that is what happened. Still waiting for the results but when I saw the surgeon afterwards she said it was probably right to remove them.

What is the dosage of the ipi + nivo combination that you use?

I have dealt with squamous cell CA for three years, but this week I was diagnosed with a large mass in my right eye that's Melanoma. I am going to be tested in a couple of days to see if it has metastasized. Eye removal and radiation have been discussed.

Today I was diagnosed with a large mass in my right eye. It is melanoma. I will have to have more testing in a few days to see if it has spread. I have been followed for squamous cell cancer and have had MOHS surgeries, besides topical chemo for precancerous areas for my legs, chest, arms and face.

Besides screening, can CRP test be another strong indication of any malognancy taking place ?

Yikes! Isn’t Til the “nuclear option”? Is it used only as a post front line Rx? Not for everyone, right?

My son has Stage 4 metastatic melanoma. He’s getting optivo and Yervoy, but I’m not sure it’s working. The tumor is localized in his left side of his neck. HELP!

😢😢😢😢😢😢

Love how positive they are.

making the sick person sicker and that is called curing the disease. That is sick.

💯❣

At 5 min 18 sec did you say Melanoma is the most common form of skin cancer? I read Basal Cell was. Melanoma is only 1%. Maybe i misunderstood you?

Thank you so much for explaining so appreciated

You all approached me re:volunteer participation in tissue study. I chose not to participate because the idea of part of me being tested etc makes me very uncomfortable. I cannot settle with that

Thank you so much. I am so grateful And I pray that God continues to bless you I really appreciate you Dr Emovon on UA-cam for restoring my health, for giving me a permanent cure to my cancer virus #dremovon....

You are a calming force Claire Casselman, thank you! (you should do a meditation/breathing/mindful-type channel, or podcast etc...youre very skilled at it. Thanks again ♥

Amazing work ! Dr. Alison🎉

how do you spell the name of the drug mentioned at 24:45 mark? thoraxin or coraxin?

(•)(•) 🎉 this is ground breaking, how does this not have a thousand 🎉🎉comments? This is a situation that everyone should be following. Leaving a . or a * Because god bless women and Gofd bless their TaTa’s (•)(•)

Going to start on Immunotherapy very soon, is there any way to help or participate in these studies? stage IV recurrent melanoma.

Stage IV starting immunotherapy within the week. Predictive bio marker would sure make the treatment done with more confidence. I am 27 i hope that with the unknown the gamble will pay off.

So interesting ! Thank you a lot for the informations.

EXCELLENT! Thanks for presenting!

No it can't

Unfortunately had to stop listening because of all the constant "Um"'s. Um, um, um...

any way to participate w bio marker technology companies in trails? is it in same clinical trail system as treatments? are bio marker technology available and used in 100s of countries or only in wealthy places?

bio marker technology - costs and broadness of bandwidth of test ? any bio marker technology stands out as future

The average person is exposed to ionizing radiation from various sources, including: Natural Background Radiation: This includes radiation from sources such as cosmic rays from outer space, radioactive materials in the Earth's crust, and radon gas that seeps into buildings from the ground. Medical Procedures: Diagnostic medical procedures such as X-rays, CT scans, and nuclear medicine exams can expose individuals to ionizing radiation. Radiation therapy for cancer treatment is another source of exposure. Consumer Products: Some consumer products, such as smoke detectors (which contain small amounts of radioactive material) and certain building materials, may emit low levels of ionizing radiation. Air Travel: Cosmic radiation exposure increases at higher altitudes, so frequent air travelers may receive slightly higher doses of ionizing radiation. The average annual dose of ionizing radiation received by the general population from natural background sources is estimated to be around 3 millisieverts (mSv) globally. However, this can vary depending on factors such as location, altitude, and lifestyle. For medical exposures, the average annual dose from diagnostic procedures is typically much lower, around 0.4 mSv per person in the United States. However, this can vary widely depending on the type and frequency of medical imaging procedures a person undergoes. Over a lifetime, the cumulative dose of ionizing radiation from all sources is estimated to be around 100 to 150 mSv for the average person. Again, this can vary depending on individual factors such as medical history and occupation. It's important to note that while ionizing radiation exposure is inevitable and occurs naturally, efforts should be made to minimize unnecessary exposure, particularly from medical procedures. Medical imaging procedures should be justified based on their potential benefits and risks, and dose optimization techniques should be employed to minimize radiation exposure while maintaining diagnostic accuracy. Overall, while ionizing radiation exposure is a part of everyday life, the doses received by the average person are typically low and unlikely to cause immediate health effects. However, it's essential to be aware of sources of radiation exposure and to take appropriate precautions to minimize unnecessary exposure whenever possible. The unit "mSv" stands for millisievert, which is a measurement of the biological effect of ionizing radiation on human tissue. Sievert (Sv) is the standard unit of dose equivalent, and one millisievert (mSv) is equal to one thousandth of a sievert. The sievert is used to quantify the potential health risks associated with exposure to ionizing radiation, taking into account the type of radiation, its energy, and the sensitivity of the irradiated tissue. It accounts for the fact that different types of radiation (e.g., X-rays, gamma rays, alpha particles) have different biological effects on the body. To put the concept into context, here are some examples of typical radiation doses: Background Radiation: The average annual dose of background radiation received by a person from natural sources is approximately 3 mSv globally. This includes radiation from cosmic rays, radioactive materials in the Earth's crust, and radon gas. Medical Procedures: The radiation dose from medical imaging procedures such as X-rays, CT scans, and nuclear medicine exams can vary widely depending on the type of procedure and the body part being imaged. For example, a chest X-ray may result in a dose of about 0.1 mSv, while a CT scan of the abdomen and pelvis may result in a dose of several millisieverts. Occupational Exposure: Workers in certain occupations, such as nuclear power plant workers, radiology technicians, and airline crew members, may receive higher radiation doses as part of their job duties. However, strict regulations and safety measures are in place to minimize occupational radiation exposure and ensure worker safety. Nuclear Accidents: In the event of a nuclear accident or radiation emergency, individuals in the vicinity may be exposed to higher levels of radiation, potentially resulting in doses that exceed typical background levels. In such situations, prompt evacuation and protective measures are essential to minimize radiation exposure and prevent adverse health effects. It's important to note that while radiation exposure is a part of everyday life, the health risks associated with low levels of radiation are generally considered to be low. However, the cumulative effects of repeated or prolonged exposure to radiation, especially at higher doses, can increase the risk of certain health effects, including cancer and other radiation-related illnesses. Overall, the concept of millisieverts provides a standardized way to measure and compare radiation doses, helping to inform decisions about radiation safety and risk management in various contexts.

is any lessening of side effects based on dose seen, is min. effective dose too elevated, can BRAF/MEK Inhibitors be admin at very very low dose and over week or two slowly ramp up to full dose? can dose be every other day every third day, effect on efficacy and side effects???? and end points.... can one be introduced at a time ramped up adding second a week later? one dose one day wait 7 days two doses over two days wait 7 days 3 doses etc etc till every day is it ever been tried? effect on efficacy and side effects???? and end points.

Thank you for the live stream and all the information. I am stage 3 a and am being treated at the University of Wisconsin in Madison.

Amtagvi needs to be indicated first line.

Why it is not working 100 percent

Fascinating!

Thanks for explaining all the stages. I'd never get that much out of a Dr visit. Found out I have a melanoma on my back and doing a Sentinal biopsy as well. Thanks for clarifying all this. For me this started with a biopsy last Aug 2023 and has taken this long, finally a surgery date in March 2024. 🙂

I am stage 4 melanoma patient from India . Please help me.

I can't believe these two would be pushing a mRNA vaccine after the disaster of the covid jab. They don't even mention sugar and glutamine as the only fuel used by cancer cells. I guess there's no money in that so who cares? Immunotherapy looks promising

I had 2 months of neoadjuvant nivolumab before surgery. During those 2 months, the sizeable lump in my neck from the affected lymph node almost went totally away. When surgery was then performed to remove the nodes in my left neck, there was considerable evidence of necrosis of the tumor. Going into the surgery knowing that the immunotherapy appeared to be working was worth waiting on the surgery because it was encouraging and gave me confidence that the adjuvant treatments (for another 10 months) would clean up anything the surgery didn't get.

10 month stage 4 melanoma survivor- Everything you presented has helped me- would love to hear you discuss limiting salt, hydrogenated oils and unnecessary additives next time. Thanks!

10 month stage 4 survivor -ipilimumab - nivolumab Thanks Doctors❤

God help people who believe what this doctor (and others like him) are selling...